Monday, June 8, 2020

ZFIN and the GRC: Supporting the zebrafish reference genome assembly


ZFIN is a member of The Genome Reference Consortium (GRC), an international collaboration consisting of NCBI, the Wellcome Trust Sanger Institute, the McDonnell Genome Institute at Washington University, the European Bioinformatics Institute (EBI) and ZFIN. This consortium is tasked with ensuring that the reference assemblies for human, mouse, zebrafish and chicken are updated and improved through new data and analysis from genome centers and the research community.

The zebrafish-specific GRC webpage (Fig. 1) provides an overview of the zebrafish genome, including an ideogram of the latest zebrafish assembly (GRCz11) that highlights the location of alternate loci scaffolds, downloadable files for the current public assemby and the tiling path files reflecting the latest assembly edits, as well as links to genome assembly data and genome regions under review. Zebrafish genome issues (Fig. 2), such as sequencing errors, gaps, and path problems, can be browsed at the chromosome level, filtered by problem type or status or searched by gene, location, clone name or accession.

If you come across what you suspect is a problem in the build in the course of your research, visit the GRC website to search the list of genome issues and if it has yet to be reported, select the "Report an Issue" tab in the header (Fig. 3) to report information about the potential problem in the build. Be as complete as possible and provide location, flanking sequences and a description of the issue. Genome annotators will evaluate the region, determine if an update to the genome is needed and submit data to create a new tiling path to improve the build with an update or "patch".

We welcome your feedback!

Figure 1 Zebrafish specific GRC webpage
Figure 1

Figure 2 Zebrafish genome issues webpage
Figure 2

Figure 3 Report a Genome Problem webpage
Figure 3

11 comments:

  1. PERMAINAN ONLINE TERBESAR DI INDONESIA

    Website paling ternama dan paling terpercaya di Asia ^^
    Sistem pelayanan 24 Jam Non-Stop bersama dengan CS Berpengalaman respon tercepat :)
    Memiliki 9 Jenis game yang sangat digemari oleh seluruh peminat poker / domino

    - Adu Q
    - Bandar Q
    - Bandar Sakong
    - Bandar Poker a
    - Poker
    - Domino 99
    - Capsa Susun
    - BANDAR66
    - PERANG BACCARAT (Games Terbaru)

    Permainan Judi online yang menggunakan uang asli dan mendapatkan uang asli ^^

    * Minimal Deposit : 20.000
    * Minimal Withdraw : 20.000
    * Deposit dan Withdraw 24 jam Non stop ( Kecuali Bank offline / gangguan )
    * Bonus REFFERAL 15 % Seumur hidup tanpa syarata
    * Bonus ROLLINGAN 0.3 % Dibagikan 5 hari 1 kali
    * Proses Deposit & Withdraw PALING CEPAT
    * Sistem keamanan Terbaru & Terjamin
    * Poker Online Terpercayaa
    * Live chat yang Responsive
    * Mensupport semua jenis bank lokal dan tersedia deposit via OVO dan PULSA TELKOMSEL serta XL


    Contact Us
    Website SahabatQQ
    WA 1 : +855887159498
    WA 2 : +855972076840
    Telegram 1 :+85515769793
    Telegram 2 : +855972076840
    LINE : SAHABATQQ
    FACEBOOK : SahabatQQ Reborn
    Agen Domino99

    ReplyDelete
    Replies
    1. anda punya masalah
      Asmara/cinta
      Uang gaib
      Santet & pelet
      Togel
      Penglaris usaha
      Saingan
      Mandul & penyakit
      Keuangan
      KONSULTASI SEKARANG JUGA ��
      �� Ustadz Abdul Nandar
      ��Whtasapp : 0853-3733-4757
      KLIK DISINI

      Delete
    2. anda punya masalah
      Asmara/cinta
      Uang gaib
      Santet & pelet
      Togel
      Penglaris usaha
      Saingan
      Mandul & penyakit
      Keuangan
      KONSULTASI SEKARANG JUGA ��
      �� Ustadz Abdul Nandar
      ��Whtasapp : 0853-3733-4757
      KLIK DISINI

      Delete
  2. Am Laura Mildred by name, i was diagnosed with Herpes 4 years ago i lived in pain with the knowledge that i wasn't going to ever be well again i contacted so many herbal doctors on this issue and wasted a large sum of money but my condition never got better i was determined to get my life back so one day i saw Mr. Morrison Hansen post on how Dr. Emu saved him from Herpes with herbal medicine i contacted Dr. Emu on his Email: Emutemple@gmail.com we spoke on the issue i told him all that i went through and he told me not to worry that everything will be fine again so he prepared the medicine and send it to me and told me how to use it, after 14 days of usage I went to see the doctor for test,then the result was negative, am the happiest woman on earth now thanks to Dr. Emu God bless you. Email him at: Emutemple@gmail.com Whats-app or Call him +2347012841542 

    ReplyDelete
  3. God bless Dr. USELU for his marvelous work in my life, I was diagnosed of HERPES SIMPLEX VIRUS since 2018 and I was taking my medications, I wasn’t satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr. USELU , how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine within 3 days. I took the medicine as prescribed by him and 2weeks later i was cured from HERPES contact him via email (dr.uselucaregiver@gmail.com) once again thanks to you Dr. USELU cure the flowing virus, contact his email or add him on whatsapp (+2347052898482) cancer cure
    diabetes cure
    ringing ear
    herpes cure
    warts cure
    HPV cure
    HIV cure
    get your ex back
    pregnancy herbal medicine
    Hepatitis

    ReplyDelete
  4. Greetings to Everyone one on this Platform Who is taking their time to Read and to The Creative mind behind this incredible Platform. I want to use this medium to let everyone know that Herpes Simplex Virus has a complete and Permanent cure and that Dr Razor Herbal Medicine is the solution. I was Diagnosed with Herpes Virus type 1 in January 16, 2015, I have made several Research Hoping to see a true Cure or Healer, Fortunately for me i saw on a blog site how Dr Razor has been saving different lives and marriages with his herbal medicine, At first i did not believe but on a second thought, i decided to give him a try, I contacted him and he assured me of a cure, he prepared the herbal medication for me, which i took for 18 days, he told me to go for a medical check up, could you believe that i was confirm Herpes type 1 Negative after the test, and i went to a different hospital and it was also Negative, I became very happy and decided to write my appreciation article about this Good man. If you are battling with this same Infection or you know of a person who is infected with any disease like Herpes, HIV, Cancer, Syphilis, Hepatitis A,B,C, all types of Cancer, Gonorrhea, life's problems that you might have etc. kindly Reach out to Doctor Razor on Email : drrazorherbalhome@gmail.com. Whatsapp/Call him on +2349065420442. Visit Doctor Razor's website : https://herbalistrazorherb.wixsite.com/drrazorherbalhome .  My Sincere Gratitude to you Sir, God will surely Keep you safe from harm's way. Please share so Other lives can be saved

    ReplyDelete
  5. God bless Dr. USELU for his marvelous work in my life, I was diagnosed of HERPES SIMPLEX VIRUS since 2018 and I was taking my medications, I wasn’t satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr. USELU , how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine within 3 days. I took the medicine as prescribed by him and 2weeks later i was cured from HERPES contact him via email (dr.uselucaregiver@gmail.com) once again thanks to you Dr. USELU cure the flowing virus, contact his email or add him on whatsapp (+2347052898482) cancer cure
    diabetes cure
    ringing ear
    herpes cure
    warts cure
    HPV cure
    HIV cure
    get your ex back
    pregnancy herbal medicine
    Hepatitis

    ReplyDelete
  6. DR OYAGU herbal medicine is a good remedy for herpes simplex virus cure. My name is MIGNON WRIGHT , am from USA,I am here to give my testimony about DR OYAGU who helped me in my life, i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by DR OYAGU, i visited different hospital but they gave me list of drugs like Familiar, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how DR OYAGU cured them, when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without any problem, my HERPES result came out negative, I pray to God to never let me and my family forget you in our life,am now cured permanently, you can also get your self cured my friends if you really need this doctor help, you can reach him now his website https://oyaguspellcaster.wixsite.com/oyaguherbalhome Email: oyaguherbalhome@gmail.com or via whatsapp +2348101755322

    ReplyDelete
  7. I want to share my happiness to the world on how i was cured from (HERPES VIRUS) by Dr Oseremen herbal , i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms, but i did not have that kind of money to buy the drugs.the one i used before did not cured me. on one faithful day, a friend of my in united kingdom told me about Dr Oseremen herbal, he told me that,it is the herbal treatment that cure is husband from hepatitis B and she told me that he have cure so many people from herpes virus with is herb medicine,then she told me to contact him that he we cure me with is herb . when i contacted Dr Oseremen, he gave me hope and say that i we be cure once i get his herbal, he send the Herbal medicine to me and i take it for two weeks and it seriously worked for me, i went to the hospital to check, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that there is no cure for herpes that is Not true, just contact him and get cure from Dr Oseremen healing herbs, he also have the herb to cure any kind of hepatitis B,C A. AND DIFFERENT KIND OF SICKNESS Remember delay in treatment leads to death.. contact Dr Oseremen on is email at (Dr.Oseremenvadi@gmail.com) or whatsapp him on is Number :+2349056394313 and he we cure you with is HEALING HERB MEDICINE , thanks to Dr  Oseremen for cure me is healing herbs medicine

    ReplyDelete
    Replies
    1. anda punya masalah
      Asmara/cinta
      Uang gaib
      Santet & pelet
      Togel
      Penglaris usaha
      Saingan
      Mandul & penyakit
      Keuangan
      KONSULTASI SEKARANG JUGA ��
      �� Ustadz Abdul Nandar
      ��Whtasapp : 0853-3733-4757
      KLIK DISINI

      Delete
  8. DON'T BELIEVE THERE IS A CURE FOR HERPES? Well here is my testimony about a doctor who helped me when I was infected with HERPES on September 22, 2014, I went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution so that my body can be okay. One day I was online and i saw the testimony of Mrs Amy Kendral speaking on how a man called Dr Razor helped her Eradicate the Herpes Simplex Infection that was eating her up every day, I Immediately emailed the Herbal Doctor Razor with the Details provided by This Woman on how to reach Him and I explained everything to him. Dr Razor told me all the things I needed to do and also gave me instructions to take a wish I followed properly. Before I knew what was happening after 18 days of taking the medication I started having changes in my body, so i told the herbalist of the development in my health and he asked me to go for a medical check up, the Doctors There were Amazed that Herpes have a Permanent and complete cured. Doctor Razor's website :  https://herbalistrazorherb.wixsite.com/drrazorherbalhome. You can Reach him on his Email via drrazorherbalhome@gmail.com . WhatsApp/Call him on +2349065420442. I made sure the Virus wasn't laying dormant in my nerve cells because I have heard of a situation like that. Before deciding to write this testimony so that many who are Battling with different kinds of Challenges Can also get cured.

    ReplyDelete