Monday, October 24, 2016

Are you familiar with CYP2D6 and its importance in drug metabolism?


CYP2D6 (Gene ID: 1565) is a gene associated with the metabolism of ~25% of clinically prescribed drugs, including antidepressants, neuroleptics and opioids. CYP2D6 is located on chromosome 22 (22q13.1), near two cytochrome P450 pseudogenes CYP2D7 and CYP2D8PBecause of its functional importance, the GRC updated the chromosomal representation for CYP2D6 to the sequence-corrected clinical standard (CYP2D6*1A) in GRCh38. The version of CYP2D6 found in the prior assembly version, GRCh37, was retained in GRCh38 as an alternate loci scaffold (KI270928.1).

The Genome Reference Consortium, in conjunction with the Pharmacogenomics Research Network, has also sought to identify and provide reference assembly representation for structural variation at the CYP2D6 locus. Much of this work was done by examining the end-sequence alignments of different fosmid libraries to the reference (Kidd et al.). As the reference assembly was known to represent CYP2D6, CYP2D7 and CYP2D8P each in single copy, we could ascertain potential duplication and deletion alleles of these genes by identification of discordant fosmid end-sequences (Figure 1).

Figure 1. Alignment of fosmid ends from the ABC12 library to GRCh38 chr. 22 in the vicinity of CYP2D6. Lines connect ends belonging to the same clone. Concordant placements (length within 3 standard deviations of the library insert average and inward facing ends) are shown in blue; clones with discordant placements are in red. 
As of the GRCh38.p7 assembly release, there are 3 alt loci and 3 novel patch scaffolds that provide representation for significant structural variation in the CYP2D6 region (Table 1). Figure 2 shows the alignment of these scaffolds to the reference chromosome, highlighting the diversity in the variant representations. An example of a CYP2D6 triplication haplotype is shown in Figure 3.

Table 1: Scaffolds providing alternate sequence representations for the CYP2D6 region, as of GRCh38.p7.
The inclusion of these additional representations for the locus in the reference assembly is intended to help in the evaluation of CYP2D6 variant alleles from other samples. The variant scaffolds can be included in the target assembly when using an alternate aware aligner, such as bwa-mem or SRPRISM, to align reads and should enable the identification of the haplotype that is the closest match to the query sample.
Figure 2. Alignment of alt loci and patch scaffolds to the CYP2D6 region of GRCh38 chr. 22. The blue bars at top represent the genomic clones comprising chr. 22. The NCBI RefSeq annotation of the chromosome is shown in the middle. The grey bars at the bottom are the alignments. Thin horizontal red lines represent deletions in the scaffolds relative to the chromosome, while vertical blue bars represent the locations of scaffold insertions.

Figure 3. Graphical view of patch scaffold NW_014040931.1, with the alignment of CYP2D6, revealing a haplotype containing a triplication of this locus.

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  3. I never believed that their could be any complete cure for Herpes 2, Mrs JANE introduce me to DR.ehiaguna a herbal doctor, who brought him back to life again. so i had to try it too and you can,t believe that in just two weeks i started using the herbal medicine he sent to me i was perfectly ok and . Right now i can tell you that few months now i have not had any symptoms of Herpes and i have just went for text last week and the doctor confirmed that there is no trace of any Herpes in my body system. Glory be to God for leading me to this genuine DR.ehiaguna I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no cure for HSV that is Not true ,just contact him and get cure from DR.ehiaguna via his Email drehiaguna@gmail.com and you will be free and free forever, Try it and you will not regret it because it truly works. One thing i have come to realize is that you never know how true it is until you try...email him drehiaguna@gmail.com.. OR WhatsApp +2348073908953 THIS IS THE TYPE OF HERBAL MEDICATION HE HAVE1 Cancer 2 Hiv 3 Low sperm count 4 Barrenness 5 Hvp 6 Herpes 7 Genital Wart 8 Rare disease 9 Hepatitis 10 Syphilis 11 DiabetesGod bless you sir for your good work that you done.....

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  4. I’m indeed very happy for the great help that Dr ehiaguna rendered to me,I was diagnosed with HSV 2 on July 7, 2018 and I have tried all possible means to get cure but all to no avail, until i saw a post in a health forum concerning herbal doctor Dr ehiaguna, who prepares herbal medicine to cure all kind of diseases/Infection including Herpes Simplex virus Type 2, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email: drehiaguna@gmail.com He assured me of a cure, he prepared a herbal medicine and sent it to me via courier service, when i received this herbal medicine, he gave me instructions on how to use it, when i applied it as instructed, i was cured of this deadly virus within 14 days of usage,he told me to go for a medical check up and i went for test, I couldn't believe i was negative and the HERPES VIRUS in my body got cured, I and my family are so happy and grateful to God for using Dr ehiaguna to Liberate me. Reach Out to this great herbal doctor via his email : drehiaguna@gmail.com you can also reach him on WhatsApp +2348073908953 God bless you

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  5. I’m indeed very happy for the great help that Dr ehiaguna rendered to me,I was diagnosed with HSV 2 on July 7, 2018 and I have tried all possible means to get cure but all to no avail, until i saw a post in a health forum concerning herbal doctor Dr ehiaguna, who prepares herbal medicine to cure all kind of diseases/Infection including Herpes Simplex virus Type 2, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email: drehiaguna@gmail.com He assured me of a cure, he prepared a herbal medicine and sent it to me via courier service, when i received this herbal medicine, he gave me instructions on how to use it, when i applied it as instructed, i was cured of this deadly virus within 14 days of usage,he told me to go for a medical check up and i went for test, I couldn't believe i was negative and the HERPES VIRUS in my body got cured, I and my family are so happy and grateful to God for using Dr ehiaguna to Liberate me. Reach Out to this great herbal doctor via his email : drehiaguna@gmail.com you can also reach him on WhatsApp +2348073908953 God bless you

    ReplyDelete
  6. tested genital herpes (HSV1-2) positive in 2019. I was having bad outbreaks. EXTREMELY PAINFUL. I have try different kinds of drugs and treatment by the medical doctors all to no avail. Six months ago I was desperately online searching for a helpful remedies for genital herpes (HSV1-2) cure, which i come across some helpful remedies on how Dr ehiaguna have help so many people in curing genital herpes (HSV1-2) with the help of herbal treatment because I too believe there is someone somewhere in the world who can cure herpes completely. As of the past 2 months, however, I've been following his herpes protocol and it stopped all outbreaks completely! To my greatest surprise I was cured completely by following the protocol of his herbal medicine . Don't be discouraged by the medical doctors. There is a cure for HSV with the help of herbs and roots by a herbalist Dr ehiaguna he is so kind and truthful with his herbal treatment you can email drehiaguna@gmail.com or massage him on WhatsApp +2348073908953 God bless you

    ReplyDelete
  7. tested genital herpes (HSV1-2) positive in 2019. I was having bad outbreaks. EXTREMELY PAINFUL. I have try different kinds of drugs and treatment by the medical doctors all to no avail. Six months ago I was desperately online searching for a helpful remedies for genital herpes (HSV1-2) cure, which i come across some helpful remedies on how Dr ehiaguna have help so many people in curing genital herpes (HSV1-2) with the help of herbal treatment because I too believe there is someone somewhere in the world who can cure herpes completely. As of the past 2 months, however, I've been following his herpes protocol and it stopped all outbreaks completely! To my greatest surprise I was cured completely by following the protocol of his herbal medicine . Don't be discouraged by the medical doctors. There is a cure for HSV with the help of herbs and roots by a herbalist Dr ehiaguna he is so kind and truthful with his herbal treatment you can email drehiaguna@gmail.com or massage him on WhatsApp +2348073908953 God bless you

    ReplyDelete
  8. I'm here to appreciate Dr Ojamo for using his herbal medicine to cure my Herpes virus, I tested positive of this virus two years ago and since then I have been suffering from this virus so one morning I was browsing through the internet then I saw several testimonies about Dr Ojamo curing people from Herpes virus and immediately I contacted him on his email >> dr.ojamoherbalhome@gmail.com and I told him about my troubles and he told me that I will get cured, He gave me some instructions which I rightly followed so he prepared a herbal medicine and sent it to me which I used for for a week and everything was like a dream to me and the Herpes virus was totally gone when I went back to the hospital and it came out negative and all the symptoms were gone. Why don't you reach him today and be free from diseases like herpes because he is a very good and honest herbal Doctor. contact him and get your life back. You can call him or whatsapp him via +2349077406037 or you can email him via>> dr.ojamoherbalhome@gmail.com

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  9. i am here to give my testimony about a doctor who save my life. i was infected with HERPES for than 2 years, I tried different doctors over a period of time but no one work, but when i came on the Internet i saw great testimony about DR USELU  how he was able to cure someone from HERPES virus with the help of herbal medicine I contacted him and he promised to cure my herpes virus.well i decided to give him a try, DR USELU put his best in it and gave me good and effective result just as he has promised. well after taking all the treatment sent to me by Dr USELU i went back to the Hospital for check up, and now i have been confirmed HERPES Negative. You can contact him if you have any kind of sickness like, HERPES, HIV, CANCER, PILE, HEPATITIS, DIABETES, and alot more you can contact him ON Whatsapp (+2347052898482) or Email dr.dr.uselucaregiver@gmail.com

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  10. powerful herbal healer called Dr. voodoo who use his natural herbs to cure
    my HIV disease I suffered from 5years, but now I am a happy woman and i am
    free from this disease that has been problem to my living, after using Dr.
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    1. Diabetes
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  11. All thanks to Dr Alli for curing my herpes virus/hpv with his herbal medicine, i do not have much to say but with all my life i will forever be grateful to him and God Almighty for using Dr Alli to reach me when i thought it was all over, today i am happy with my life again after the medical doctor have confirmed my HERPES SIMPLEX VIRUS / HPV of 5 is gone,i have never in my life believed that HERPES SIMPLEX VIRUS could be cured by herbal medicine. so i want to use this means to reach other persons who have this disease by testifying the power of Dr Alli that all hope is not lost yet, try and contact him by any means for any kind of disease with his email: ( Allispellhelp1@gmail.com ) or his whatsapp number +2348100772528 and get your healing

    ReplyDelete
  12. God bless Dr. maggi for his marvelous work in my life, I was diagnosed of Hsv and I was taking my medications, I wasn’t satisfied i needed to get the Hsv out of my system, I searched about some possible cure for Hiv, i saw a comment about Dr. maggi, how he cured HIV, HERPES, DIABETES and CANCER with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my healing, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by and 8 days later i was cured from Hsv, Dr. Maggi truly, you are great, do you need his help also? Why don’t you contact him through drmaggiherbalhome@gmail.com or whatsApp him on+19179796387

    ReplyDelete
  13. I have been suffering from Human papillomavirus (HPV) for 2years, I was given some tablets at the hospital but I refused to take it, They said I have to be on it for life so I don't want take a drugs everyday for life. No point in taking medicine everyday when u won't get cure from it and I was advice to seek for natural herbal cure, after some time I found dr Ehimare is the most trustful herbalist that have herbs to cure wicked symptom's,I emailed dr Ehimare, for 2weeks been his patient he cured my (HPV) with his herbal. I only used his natural herbs for two weeks it was 100% cure. I'm not (HPV) patient anymore. I'm happy about it i finally got cured out of this mess been in my body for 2years. I also recommend you if you're living with (HPV) or herpes symptoms i also want you to be free contact dr Ehimare with the email attach to my post. drehimare3@gmail.com or whatsapp him on +1 (267) 691-1087

    ReplyDelete
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  15. Hello everyone. Dr. Maggi Herbs is a good remedy for herpes Virus , I was a carrier of herpes virus and I saw a testimony on how Dr. Maggi cure Herpes Virus, I decided to contact him, I contacted him and he guided me. I asked him for solutions and he started the remedies for my health. After he finished he sent me the herbs which I took for 2 weeks before asking me to go for a check up and getting there. I could not believe that I was confirmed HSV 2 Negative after the test, Today I am so happy because I'm free from herpes disease with the help of Dr. Maggi. Thank God now everything is fine, I'm cured by Dr. Maggi herbal medicine, I'm very thankful to God for making it possible. You can reach him by email, I strongly recommend him to anyone out here looking for a cure.Contact Dr Maggi via email: drmaggiherbalhome@gmail.com call or whatsApp him on+1(917) 979-6387.

    ReplyDelete
  16. I tested positive for HSV-2 a few months ago. At first, yes, I was devastated thinking I have an incurable STD for life. After doing hours of research I quickly realized genital herpes is a filthy parasite that just likes to hide in your body. Yes, there’s no “medical cure” but that doesn’t mean your body can’t get rid of it. I literally flush it out of my system with the help of Dr. Azu natural herbal medication which I ordered after doing some research. And now I’m HSV-2 Negative, I never believed it until my doctor finally gave me the test results and behold I was HSV free. I’m so glad that I found you Dr. Azu. Thanks so much for your goodness I’m grateful. You can also get your help from him through his Whats App Contact for fast communication +2347087313747 OR Email:dr.azuherbalhome@gmail.com .

    ReplyDelete
  17. i am mercy jesae from California, i have been surfing from Herpes Disease for past 2years now, the experiences was really bad, i was passing through a lot of hard times.. some of my symptoms where anxiety or apathy and fatigue, dizziness, poor balance, one day i was searching through the internet for natural remedies for Herpes Disease, i saw several post about this dr called "DR MAGGI" cure for Herpes Disease, and some Diseases, so i was very convinced and ready to be cured with their natural remedies, so i contacted him and i purchased some herbal medicine for the cure, after few days of usage about two weeks i was free completely of the symptoms and went for a test and i can say now i am free from Herpes Disease totally.... indeed their remedies are super effective... contact Dr Maggi today on his email: drmaggiherbalhome@gmail.com or call or whatsApp him +1 (917) 979-6387.

    ReplyDelete
  18. Get rid of all kinds of Herpes with Natural Root and Herbs, I was once infected with Herpes Genital Warts and after using Dr Enato herbal Medicine for a couple of weeks I couldn't trace it anymore, I even went for a checkup and there my test came out Negative. Get Your cure today from his herbal medicine contact, dr.enatoherbalcure@gmail.com or WhatsApp {+2348071351544}

    ReplyDelete
  19. I thought I was never going to get the cure for Herpes as I was told by my family doctor, Just last month I heard some person saying about Dr. Enato herbal home who use natural herbs to cure HSV and I emailed him for a question and he proved his cure to my satisfaction & more evidence. I asked for the cure and after taking it for 3 weeks i was free from herpes virus, definitely his natural herbs cured my HSV Thank you Dr. Enato Contact him via dr.enatoherbalcure@gmail.com or call/WhatsApp +2348071351544

    ReplyDelete
  20. Natural herbs have cured so many illness that drugs and injection cant cure. I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. I read people's testimonies online on how they were cured of herpes, HIV, diabetics etc by  DR. Enato herbal medicine, so I decided to contact the doctor because I know nature has the power to heal anything. I was diagnosed with Herpes virus for the past 3 years but  DR. Enato cured me with his herbs and I referred my aunt and her husband to him immediately because they were both suffering from HIV but to God be the glory, they were cured too .I know it is hard to believe but I am a living testimony. There is no harm trying herbs. He is also a spell caster,he casts spells to restore broken marriages and good luck spells to prosper and excel in life.Contact  DR. Enato on his email ; dr.enatoherbalcure@gmail.com call or Whatsapp (+2348071351544)

    ReplyDelete
  21. Hello everyone out there, I'm here to give my testimony about a herbalist doctor who helped me. I was infected with HERPES SIMPLEX VIRUS in 2011, I went to many hospitals to heal myself but there was no solution, so I was thinking how I can get a solution so that my body can be well. One day I was in the river thinking about where I can go to get a solution. so a lady walked towards me telling me why I'm so sad and I open everything by telling her my problem, she told me she could help me, she introduced me to a doctor who uses herbal medicines to cure the SIMPLEX HERPES VIRUS and gave me your email, so I sent you an email. He told me everything I had to do and also gave me instructions to take, which I followed correctly. Before I knew what was happening after two weeks, the SIMPLEX HERPES VIRUS that was in my body disappeared. therefore, if you also have a broken heart and need help, you can also send an email to {dr.joshuaherbalhome6@gmail.com} or whatsapp him on +2347048515927 Contact him today and he will have a testimony ... Good luck!

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    ReplyDelete
  22. I was diagnosed with HERPES virus and I have tried all I can to get cured but all to no avail, until I saw a post in a health forum about a herbalist named Dr. Enato who prepares herbal medications to cure all kind of diseases including HERPES virus. At first I doubted if it was real but decided to give it a try. when I contacted this herbalist via his email and he prepared a HERPES herbal cure and sent it to me via UPS delivery service. When I received this herbal medicine, he gave me steps and directions on how to apply it, after applying the way I was instructed, I was totally cured of this deadly disease called HERPES. All thanks to Dr. Enato for helping me get rid of this virus. Contact the herbal doctor via whatsapp +2348071351544 OR email:(dr.enatoherbalcure@gmail.com)or via his website https://drenatoherbalcure.simdif.com/ He can also cure the following disease as well(1)Alzheimer (2)Cancer(3)HIV(4)Herpes(5)Genital warts(6)ALS(7)Virginal infection(8)HPV(9)Hepatitis(10)Asthma

    ReplyDelete
  23. Hello everyone. Dr. Maggi Herbs is a good remedy for herpes Virus , I was a carrier of herpes virus and I saw a testimony on how Dr. Maggi cure Herpes Virus, I decided to contact him, I contacted him and he guided me. I asked him for solutions and he started the remedies for my health. After he finished he sent me the herbs which I took for 2 weeks before asking me to go for a check up and getting there. I could not believe that I was confirmed HSV 2 Negative after the test, Today I am so happy because I'm free from herpes disease with the help of Dr. Maggi. Thank God now everything is fine, I'm cured by Dr. Maggi herbal medicine, I'm very thankful to God for making it possible. You can reach him by email, I strongly recommend him to anyone out here looking for a cure.Contact Dr Maggi via email: drmaggiherbalhome@gmail.com call or whatsApp him on+1(917) 979-6387.

    ReplyDelete
  24. I have been suffering from Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr Ogedegbe on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr Ogedegbe today on this Email address: dr.ogedegbe6@gmail.com or WhatsApp him on this Number +2348109374702  .... thanks to you dr Ogedegbe

    ReplyDelete
  25. Greatest thanks to Dr Omon for his herbal medicine that he prepared for me and when I start using it in just 2weeks I was completely cured and that ended my HERPES SIMPLEX 1&2 VIRUS i am so happy and grateful to Dr Omon . after reading about him on a testimony of Jason on a blogger. I knew suddenly Dr Omon was the right Doctor to cure my HERPES SIMPLEX 1&2 VIRUS. I discuss with Dr Omon and he prepared a herbal medicine for me and when it got sent to me in California. I used the herbal medicine in 2weeks and i went for check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Omon also has remedy to others DISEASES & VIRUSES like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I obligate everyone to contact this powerful herbalist Dr Omon and be free from your suffering. contact his WhatsApp line: +2348108885329 or visit his Website https://dromon.mystrikingly.com/ Email: dromon124@gmail.com

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  27. I’m here to testify about the great work Dr OMOBUAN did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr Smith on how he cured her from HIV Virus. And she also gave the email address of this man and advise anybody to contact Dr OMOBUAN for help for any kind of sickness that he would be of help, so I emailed him on ( christianomobuan4825@gmail.com ) telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr OMOBUAN assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact Dr OMOBUAN via email. { christianomobuan4825@gmail.com } or whatsapp him on(+2348140903559 ) DR OMOBUAN CAN AS WELL CURE THE FOLLOWING DISEASE:- HIV/AIDS HERPES CANCER ALS hpv eye problem etc.

    ReplyDelete
  28. I tested positive for HSV-2 a few months ago. At first, yes, I was devastated thinking I have an incurable STD for life. After doing hours of research I quickly realized genital herpes is a filthy parasite that just likes to hide in your body. Yes, there’s no “medical cure” but that doesn’t mean your body can’t get rid of it. I literally flush it out of my system with the help of Dr. Azu natural herbal medication which I ordered after doing some research. And now I’m HSV-2 Negative, I never believed it until my doctor finally gave me the test results and behold I was HSV free. I’m so glad that I found you Dr. Azu. Thanks so much for your goodness I’m grateful. You can also get your help from him through his Whats App Contact for fast communication +2347087313747 OR Email:dr.azuherbalhome@gmail.com .....

    ReplyDelete
  29. READ TO CHOOSE THE RIGHT DOCTOR FOR A TRUE CURE OF HERPES SIMPLEX VIRUS AND HIV
    Sometimes we just have to try herbal medicine to see for ourselves. I am very happy today that I am not listening to what people are saying, otherwise I would be dead by now. I was infected with HERPES SIMPLEX VIRUS in 2014, I went to many hospitals for treatment but there was no solution. One day I was at the office wondering where I could find a solution. then a lady approached me telling me why i am so sad and i open everything to her to tell her my problem, she told me that she can help me, she introduces me to a doctor who uses herbal medicine to cure HERPES SIMPLEX VIRUS, HIV and many other diseases and she gave me the doctor's email so I emailed her. He told me everything I had to do and sent the herbal medicine to me by courier delivery service and also gave me instructions to take, which I followed correctly. Before I knew what was happening after three weeks, the HERPES SIMPLEX virus in my body was gone and the blisters were gone. I went to the hospital for a test and it was negative. This man is real and he has the solution to the herpes virus. So if you are also heartbroken and need some help, you can also email (usmandrhazim@gmail.com). (call or WhatsApp +2349058026857 according to this great DR, it can also treat HIV, ALS, CANCER, hepatitis and diabetes).

    ReplyDelete
  30. When I was living with the virus HSV2, I thought I was doomed, as so many people forced me to believe the no cure idea but that changed the moment I contacted dr.azuherbalhome@gmail.com, My hope was brought back alive by the comforting words of the doc,.. Dr. Azu placed me on a three weeks natural herbal medication body flush and at the end of it my subsequent test result came out Negative and I now have a normal life free from disease, say no to HERPES, visit dr.azuherbalhome@gmail.com Today for help. say a big NO to diseases. For fast communication whats App contact +2347087313747.

    ReplyDelete
  31. FINALLY FREE FROM HERPES VIRUS. what a miracle i never believe there is cure because my doctor tested me herpes positive and she told me there is no cure, i’m very happy today that i’m having a free life without this herpes virus, i can remember some months ago when i was crying all through the night and day that i can’t get cured from this herpes, i found this herbal man called Dr Ehizele on internet when i was doing research on cure for shingle i contacted him to found out if i can get help from this herpes virus, i was so surprise when he told me that he have the herbs cure to it and he sent me the herbal in less down 5 days i was so happy when i get someone giving me hope that he can cured me i took the herbal for just 2 weeks, when i went for test after taking the herbal i found out that i am cured i was so happy and surprise, i want to use this opportunity to inform you that there is cured to herpes virus you can also contact him for his help as soon as possible so that you can get rid of this herpes once and for all you can reach him through this email: ehizeleherbalhome@gmail.com, whatsApp him on +2347089384319 or visit him on his facebook page @Dr Ehizele

    ReplyDelete
  32. I was diagnosed with the HERPES virus and I have tried everything possible to cure myself, but all to no avail, until I saw a post in a health forum about a doctor preparing herbal medicines to cure  HERPES virus, at first I doubted it was real, but decided to give it a try, when I contacted  Dr.Ishiaku on whatsapp (+2348180828544) and he prepared medicine and sent it to me with the help of  DHL delivery company, when I received this herbal medicine, he gave me step-by-step instructions on how to apply it, after applying it the way they directed me, I was totally cured of this deadly disease called HERPES, all thanks  to Dr. Ishiaku

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  35. I am now leaving a healthy life after using the herbal medicine to cure myself from herpes, i am now herpes disease free after the application and usage. You can contact him for your herbal medication from via Email Robinsonbuckler11@gmail com. Thanks and God Bless you for your help, referring people with herpes disease to use this herbal remedy__________________________🌿🌿🌿

    Good for the following

    Shingles,

    Cold sore,

    HPV,

    HSV1&2,

    ReplyDelete
  36. I have been suffering from Herpes for the past 4 years and 2 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of  Dr.Puma on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which I took according to his instructions. When I was done taking the herbal medicine I went for a medical checkup and to my greatest surprise I was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr.Puma today on this Email address: lalapumaspelltemple@gmail.com or WhatsApp him on this Tell.Number +233507754985   

    ReplyDelete
  37. Before now, I had suffered from HIV/AIDS disease for 3 years and had constant pain, especially in my body. The Virus circulated all over my body system and i have been taking treatment from my doctor, few weeks ago i search on the internet if i could get any information concerning the cure for my HIV, on my search i saw a testimony of someone who has been healed from HIV by a herbal doctor called DR ODUWA and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to DR ODUWA telling him about my HIV/AIDS he told me not to worry anymore that i will be fine. we discussed further and gave instructions to me and i followed. I didn't believe him, until i received the package of some herbal stuffs, roots and herbs and some herbal soap and a written note he sent to me via DHL delivery service, i was applying the various remedies as he wrote on he note.

    5 days later, i noticed that there was a positive change going on in my body system. Gradually i was taking the cure and now, i am very healthy again. Even the test now shows negative.
    I promised DR ODUWA that i will always testify about his cure.

    send an email to him at: dr.oduwaspellhome@gmail.com or whatsapp him +2348054527244 , you can confirm me on this email Emmanuelebhomenmen@gmail.com

    ReplyDelete
  38. getting drugs from the hospital to keep me and my son healthy, it got to a point that i was waiting for death to come because i was broke, one day i heard about this great man called Dr Erickson who is well known for Herpes, kidney stones, and Cancer cure, i decided to message him I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared a herbal medicine (CURE) and, he gave my details to the Courier Office. they told me that 4-8 days I will receive the package and after receiving it, i took the medicine as prescribed by him at the end of the two weeks, he told me to go to the hospital for a checkup, and i went, surprisingly after the test the doctor confirm me kidney stones free, and my son and i thought it was a joke, i went to other hospital and was also the same, thank you for saving our life's, I promise I will always testify of your good works. If you are c, contact him and I am sure you will get cured, contact him pagegetting drugs from the hospital to keep me and my son healthy, it got to a point that i was waiting for death to come because i was broke, one day i heard about this great man called Dr Erickson who is well known for Herpes, kidney stones, and Cancer cure, i decided to message him I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared a herbal medicine (CURE) and, he gave my details to the Courier Office. they told me that 4-8 days I will receive the package and after receiving it, i took the medicine as prescribed by him at the end of the two weeks, he told me to go to the hospital for a checkup, and i went, surprisingly after the test the doctor confirm me HSV1, and my son and i thought it was a joke, i went to other hospital and was also the same, thank you for saving our life's, I promise I will always testify of your good works. If you are c, contact him and I am sure you will get cured, contact him pageDr Erickson herbal root getting drugs from the hospital to keep me and my son healthy, it got to a point that i was waiting for death to come because i was broke, one day i heard about this great man called Dr Erickson who is well known for Herpes, kidney stones, and Cancer cure, i decided to message him I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared a herbal medicine (CURE) and, he gave my details to the Courier Office. they told me that 4-8 days I will receive the package and after receiving it, i took the medicine as prescribed by him at the end of the two weeks, he told me to go to the hospital for a checkup, and i went, surprisingly after the test the doctor confirm me HSV free, and my son and i thought it was a joke, i went to other hospital and was also the same, thank you for saving our life's, I promise I will always testify of your good works. If you are c, contact him and I am sure you will get cured, contact him pageDr Erickson herbal root
    via: dr.oduwaspellhome@gmail.com or whatsapp him at +2349169329172.
    THESE ARE THE THINGS
    HSV1/2
    HPV
    HERPES
    . COLD SORE
    . HIV/AIDS
    . CANCER
    . kidney stones
    . LASSA FEVER
    via: dr.oduwaspellhome@gmail.com or whatsapp him at +2349169329172.
    THESE ARE THE THINGS
    . COLD SORE
    . HIV/AIDS
    . CANCER
    . kidney stones
    . LASSA FEVER

    ReplyDelete
  39. I have got genital Herpes virus for some years and recently I was searching for updates online for the virus when I saw testimonies on how a herbal doctor cures Herpes with herbal meds so I decided to contact him and he guided me on what to do and he prepared and send the meds for me to drink and to my surprise I just tested negative for the second time on different lab. All the symptoms were gone immediately I stared drinking the meds! I cant believe that I got cured just by drinking a herbal medicine so I'm very grateful to this herbal doctor. reach him on his website https://excelherbalcure.com

    ReplyDelete
  40. Greetings everyone that will listen to my story. I was heartbroken and depressed when I got diagnosed of Genital herpes.. I was given some pills to “take called aclyclovir which even made me more sick and gave me headaches to the point of me puking. I searched everywhere for a solution then I came across this herbal doctor called Excel who gave me hope that he can cure me totally from the virus with his herbal medication so I gave it a try and he prepared and send me the medication through DHL and I drink it for several days, the sores were the first to go away and I have just tested negative to the virus for the second time. believe me this is real! Get to know about this herbal man and his medication on his website https://excelherbalcure.com

    ReplyDelete